We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Tetraspanins: Host Factors in Viral Infections.
- Authors
New, ChihSheng; Lee, Zhao-Yong; Tan, Kai Sen; Wong, Amanda Huee-Ping; Wang, De Yun; Tran, Thai
- Abstract
Tetraspanins are transmembrane glycoproteins that have been shown increasing interest as host factors in infectious diseases. In particular, they were implicated in the pathogenesis of both non-enveloped (human papillomavirus (HPV)) and enveloped (human immunodeficiency virus (HIV), Zika, influenza A virus, (IAV), and coronavirus) viruses through multiple stages of infection, from the initial cell membrane attachment to the syncytium formation and viral particle release. However, the mechanisms by which different tetraspanins mediate their effects vary. This review aimed to compare and contrast the role of tetraspanins in the life cycles of HPV, HIV, Zika, IAV, and coronavirus viruses, which cause the most significant health and economic burdens to society. In doing so, a better understanding of the relative contribution of tetraspanins in virus infection will allow for a more targeted approach in the treatment of these diseases.
- Subjects
VIRUS diseases; INFLUENZA viruses; HIV; COMMUNICABLE diseases; COVID-19; THERAPEUTICS; PAPILLOMAVIRUS diseases
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 21, p11609
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms222111609