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- Title
Porphyrin Based 2D-MOF Structures as Dual-Kinetic Sorafenib Nanocarriers for Hepatoma Treatment.
- Authors
Bieniek, Adam; Wiśniewski, Marek; Czarnecka, Joanna; Wierzbicki, Jędrzej; Ziętek, Marcin; Nowacki, Maciej; Grzanka, Dariusz; Kloskowski, Tomasz; Roszek, Katarzyna
- Abstract
The existing clinical protocols of hepatoma treatment require improvement of drug efficacy that can be achieved by harnessing nanomedicine. Porphyrin-based, paddle-wheel framework (PPF) structures were obtained and tested as dual-kinetic Sorafenib (SOR) nanocarriers against hepatoma. We experimentally proved that sloughing of PPF structures combined with gradual dissolving are effective mechanisms for releasing the drug from the nanocarrier. By controlling the PPF degradation and size of adsorbed SOR deposits, we were able to augment SOR anticancer effects, both in vitro and in vivo, due to the dual kinetic behavior of SOR@PPF. Obtained drug delivery systems with slow and fast release of SOR influenced effectively, although in a different way, the cancer cells proliferation (reflected with EC50 and ERK 1/2 phosphorylation level). The in vivo studies proved that fast-released SOR@PPF reduces the tumor size considerably, while the slow-released SOR@PPF much better prevents from lymph nodes involvement and distant metastases.
- Subjects
NANOMEDICINE; SORAFENIB; CANCER cell proliferation; NANOCARRIERS; HEPATOCELLULAR carcinoma; PORPHYRINS
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 20, p11161
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms222011161