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- Title
Mitochondrial Dysfunction and Heart Disease: Critical Appraisal of an Overlooked Association.
- Authors
Bisaccia, Giandomenico; Ricci, Fabrizio; Gallina, Sabina; Di Baldassarre, Angela; Ghinassi, Barbara
- Abstract
The myocardium is among the most energy-consuming tissues in the body, burning from 6 to 30 kg of ATP per day within the mitochondria, the so-called powerhouse of the cardiomyocyte. Although mitochondrial genetic disorders account for a small portion of cardiomyopathies, mitochondrial dysfunction is commonly involved in a broad spectrum of heart diseases, and it has been implicated in the development of heart failure via maladaptive circuits producing and perpetuating mitochondrial stress and energy starvation. In this bench-to-bedside review, we aimed to (i) describe the key functions of the mitochondria within the myocardium, including their role in ischemia/reperfusion injury and intracellular calcium homeostasis; (ii) examine the contribution of mitochondrial dysfunction to multiple cardiac disease phenotypes and their transition to heart failure; and (iii) discuss the rationale and current evidence for targeting mitochondrial function for the treatment of heart failure, including via sodium-glucose cotransporter 2 inhibitors.
- Subjects
MYOCARDIAL reperfusion; HEART diseases; SODIUM-glucose cotransporter 2 inhibitors; MITOCHONDRIA; GENETIC disorders; HEART failure
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 2, p614
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms22020614