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- Title
Oral Submucous Fibrosis: A Review on Etiopathogenesis, Diagnosis, and Therapy.
- Authors
Shih, Yin-Hwa; Wang, Tong-Hong; Shieh, Tzong-Ming; Tseng, Yu-Hsin
- Abstract
Oral submucous fibrosis (OSF) is characterized by abnormal collagen deposition. It is a precancerous disorder and transforms into a malignant tumor in 1.5–15% of all cases. Symptoms include submucous fibrosis, ulceration, xerostomia, a burning sensation, and restricted mouth opening. All of these greatly interfere with patient quality of life. The present review introduces OSF from a molecular perspective and summarizes what is known about its underlying mechanisms, diagnostic biomarkers, and therapeutic interventions. In addition to the aggressive treatment of OSF, its prevention is also important. Future research should, therefore, focus on improving the oral health literacy of the patients susceptible to OSF.
- Subjects
ORAL submucous fibrosis; HEALTH literacy; BRAILLE; CANCER
- Publication
International Journal of Molecular Sciences, 2019, Vol 20, Issue 12, p2940
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms20122940