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- Title
CD146 Expression Correlates with Epithelial-Mesenchymal Transition Markers and a Poor Prognosis in Gastric Cancer.
- Authors
Wen-Fang Liu; Shu-Rong Ji; Jian-Jun Sun; Yi Zhang; Zhong-Yan Liu; Ai-Bin Liang; Hua-Zong Zeng
- Abstract
CD146 has been regarded as a novel potential therapeutic target for multiple cancers. The aim of the study was to investigate the expression of CD146 in gastric cancer and evaluate its clinical-pathological and prognostic significance. The expression of CD146 and three epithelial-mesenchymal transition (EMT)-related proteins (E-cadherin, β-catenin and vimentin) was examined in 144 gastric cancers by immunohistochemistry. Fifty-nine cases (41.0%) were defined as positive for CD146 expression. We found that CD146 expression correlated positively with lymph node involvement and a poor prognosis, and retained an independent prognostic factor for gastric cancer patients. Furthermore, positive expression of CD146 was strongly associated with loss of the epithelial marker E-cadherin and acquisition of the expression of the mesenchymal markers nuclear β-catenin and vimentin. These findings suggest that CD146 might promote EMT and progression in gastric cancer, and thus may be a potential therapeutic target for patients with gastric cancers.
- Subjects
STOMACH cancer; EPITHELIAL cells; MESENCHYMAL stem cells; GENETIC markers; GENE expression; IMMUNOHISTOCHEMISTRY; CLINICAL trials; CANCER patients; CANCER treatment; PROGNOSIS
- Publication
International Journal of Molecular Sciences, 2012, Vol 13, Issue 5, p6399
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms13056399