We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Do partial AZFc deletions affect the sperm retrieval rate in non-mosaic Klinefelter patients undergoing microdissection testicular sperm extraction?
- Authors
Huang, I-Shen; Fantus, Richard J.; Chen, Wei-Jen; Wren, James; Kao, Wei-Tang; Huang, Eric Yi-Hsiu; Bennett, Nelson E.; Brannigan, Robert E.; Huang, William J.
- Abstract
<bold>Background: </bold>The purpose of this study is to evaluate the prognostic factors for sperm retrieval and determine if Y chromosome deletion is associated with deleterious effects on spermatogenesis in non-mosaic Klinefelter patients. Whether Y chromosome deletion determines the sperm retrieval rate in non-mosaic Klinefelter patients has not yet been addressed.<bold>Methods: </bold>We retrospectively collected medical records of azoospermic patients from Sep 2009 to Dec 2018, and enrolled 66 non-mosaic 47, XXY patients who were receiving mTESE. The predictive values of patients age, serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, prolactin, estradiol and Y chromosome deletion were assessed for successful sperm recovery.<bold>Results: </bold>Testicular sperm recovery was successful in 24 (36.4%) of 66 men. The mean age (36.0 vs. 36.6 years), and levels of FSH (30.0 vs 36.9 IU/L), LH (17.7 vs 21.9 IU/L), testosterone (2.4 vs. 2.1 ng/ml), prolactin (9.1 vs. 8.8 ng/ml), and estradiol (19.4 vs. 22.3 pg/ml) did not show any significant difference when comparing patients with and without successful sperm retrieval. Partial deletion of azoospermic factor c (AZFc) was noted in 5 (20.8%) of 24 patients with successful sperm retrieval, including three b2/b3 and two gr/gr deletion cases, whereas 4 (9.5%) of 42 patients with unsuccessful sperm retrieval were noted to have AZFc partial deletion (one b2/b3, one sY1206 and two gr/gr deletion), though the difference was not statistically significant (p = 0.27).<bold>Conclusion: </bold>According to present results, age and AZFc partial deletion status should not be a deterrent for azoospermic males with non-mosaic Klinefelter syndrome to undergo mTESE.
- Subjects
SPERMATOZOA; Y chromosome; MICRODISSECTION; KLINEFELTER'S syndrome; FOLLICLE-stimulating hormone; HUMAN artificial insemination; TESTIS physiology; SPERMATOZOA physiology; TESTIS surgery; GENETIC mutation; RETROSPECTIVE studies; INFERTILITY; RESEARCH funding; COLLECTION &; preservation of biological specimens; ORGAN donation
- Publication
BMC Urology, 2020, Vol 20, Issue 1, p1
- ISSN
1471-2490
- Publication type
journal article
- DOI
10.1186/s12894-020-00587-5