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- Title
Is Small Prostate Volume a Predictor of Gleason Score Upgrading after Radical Prostatectomy?
- Authors
Mun Su Chung; Seung Hwan Lee; Dong Hoon Lee; Byung Ha Chung
- Abstract
Purpose: We aimed to analyze the relationship between prostate volume and Gleason score (GS) upgrading [higher GS category in the radical prostatectomy (RP) specimen than in the prostate biopsy] in Korean men. Materials and Methods: We retrospectively analyzed the medical records of 247 men who underwent RP between May 2006 and April 2011 at our institution. Transrectal ultrasound (TRUS) volume was categorized as 25 cm³ or less (n=61), 25 to 40 cm³ (n=121) and greater than 40 cm³ (n=65). GS was examined as a categorical variable of 6 or less, 3+4 and 4+3 or greater. The relationship between TRUS volume and upgrading of GS was analyzed using multivariate logistic regression. Results: Overall, 87 patients (35.2%) were upgraded, 20 (8.1%) were downgraded, and 140 (56.7%) had identical biopsy and pathological Gleason sum groups. Smaller TRUS volume was significantly associated with increased likelihood of upgrading (p trend=0.022). Men with prostates 25 cm3 or less had more than 2.7 times the risk of disease being upgraded relative to men with TRUS volumes more than 40 cm3 (OR 2.718, 95% CI 1.403-8.126). Conclusion: In our study, smaller prostate volumes were at increased risk for GS upgrading after RP. This finding should be kept in mind when making treatment decisions for men with prostate cancer that appears to be of a low grade on biopsy, especially in Asian urologic fields.
- Subjects
PROSTATE physiology; PROSTATECTOMY; GLEASON grading system; BIOPSY; PROSTATE cancer; COMPARATIVE studies
- Publication
Yonsei Medical Journal, 2013, Vol 54, Issue 4, p902
- ISSN
0513-5796
- Publication type
Article
- DOI
10.3349/ymj.2013.54.4.902