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- Title
Syntheses, Characterization, and Antibacterial Activities of Four New Schiff Base Compounds Derived from 1-Phenyl-3-methyl-4-benzoyl-2-pyrazolin-5-one.
- Authors
Liu, Chong-Bo; Chen, Yuan; Yan, Liu-Shui; Huang, De-He; Xiong, Zhi-Qiang
- Abstract
Four new Schiff bases were designed and synthesized. 5-Methyl-4-(4-aminophenylamino-phenyl-methylene)-2-phenyl-2,4-dihydro-pyrazol-3-one (compound 1) and 5-methyl-4-(2-aminophenylamino-phenyl-methylene)-2-phenyl-2,4-dihydro-pyrazol-3-one (compound 2) were synthesized by interaction of 1-phenyl-3-methyl-4-benzoyl-2-pyrazolin-5-one (PMBP) with o- and p-phenylenediamine, respectively; 4,4′-(1,2-phenylenebis(azanediyl)bis(phenylmethanylylidene))bis(3-methyl-1-phenyl-1H-pyrazol-5(4H)-one) (compound 3) and 5-methyl-4-(phenyl(2-((3-phenylallylidene)amino)phenylamino)methylene)-2-phenyl-2,4-dihydro-pyrazol-3-one (compound 4) were synthesized by interaction of compound 2 with PMBP and cinnamaldehyde in an ethanolic medium, respectively. The molecular structures of the title compounds were first characterized by single-crystal X-ray diffraction, mass spectrometry, and elemental analysis. The title compounds were tested for antibacterial activity ( Escherichia coli, Staphylococcus aureus, and Bacillus subtilis) by disk diffusion method.
- Subjects
ORGANIC synthesis; ANTI-infective agents; SCHIFF bases; PYRAZOLINONES; PHENYLENEDIAMINES; MASS spectrometry; MOLECULAR structure
- Publication
Journal of Heterocyclic Chemistry, 2012, Vol 49, Issue 4, p839
- ISSN
0022-152X
- Publication type
Article
- DOI
10.1002/jhet.874