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- Title
Multi-frequency electromagnetic radiation induces anxiety in mice via inflammation in the cerebral cortex.
- Authors
Jing, Xu; Menghua, Li; Lihui, Zhang; Qian, Wei; Xueli, Wang; Xuelong, Zhao; Zhihui, Li; Guofu, Dong; Changzhen, Wang
- Abstract
Modern life is filled with radiofrequency electromagnetic radiation (RF-EMR) in various frequency bands, while the health risks are not clear. In this study, mice were whole-body exposed to 0.9/1.5/2.65 GHz radiofrequency radiation at 4 W/kg for 2 h per day for 4 weeks to investigate the emotional effects. It was found that the mice showed anxiety but no severe depression. The ELISA results showed a significant decrease in amino acid neurotransmitters (GABA, DA, 5-HT), although acetylcholine (ACH) levels were not significantly altered. Furthermore, Western blot results showed that BDNF, TrkB, and CREB levels were increased in the cerebral cortex, while NF-κB levels were decreased. In addition, pro-inflammatory factors (IL-6, IL-1β, TNF-α) were significantly elevated, and anti-inflammatory factors (IL-4, IL-10) tended to decrease. In conclusion, multi-frequency electromagnetic radiation induces an inflammatory response through the CREB-BDNF-TrkB and NF-κB pathways in the cerebral cortex and causes a decrease in excitatory neurotransmitters, which ultimately causes anxiety in mice.
- Subjects
ELECTROMAGNETIC radiation; CEREBRAL cortex; AMINO acid neurotransmitters; ANXIETY; MICE; PSILOCYBIN
- Publication
Environmental Science & Pollution Research, 2024, Vol 31, Issue 24, p35161
- ISSN
0944-1344
- Publication type
Article
- DOI
10.1007/s11356-024-33447-y