We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Protective properties of Spondias mombin Linn leaves on redox status, cholinergic dysfunction and electrolyte disturbance in cyanide-intoxicated rats.
- Authors
Akinmoladun, Afolabi Clement; Adelabu, Adesola Adebusayo; Saliu, Ibrahim Olabayode; Adetuyi, Aanuoluwapo Ruth; Olaleye, Mary Tolulope
- Abstract
Cyanide is an environmental neurotoxin which has been reported to arrest the normal functioning of the brain. This study investigated the protective properties of methanol and flavonoid-rich extracts of the leaves of Spondias mombin on redox status, cholinergic dysfunction and electrolyte disturbance in cyanide-induced neurotoxicity in rats. Male Wistar rats were orally pre-treated with Spondias mombin methanol leaf extract (SMC) (50, 100 and 150 mg/kg), flavonoid-rich extract (SMF) (25, 50 and 75 mg/kg) or quercetin (20 mg/kg), followed by intraperitoneal administration of 2 mg/kg potassium cyanide. Cyanide intoxication caused brain damage in rats as echoed in the deleterious alterations to activities/levels of endogenous antioxidants and biomarkers/enzymes linked with electrolyte imbalance and neurotoxicity. Pre-treatment with SMC and SMF significantly attenuated these KCN-induced imbalances (p < 0.05). The results suggested that the protection conferred by SMC and SMF probably involves attenuation of oxidative stress and regulation of ionic homeostasis. SMF displayed a better apparent ameliorative activity than SMC and 75 mg/kg SMF offered the best protection suggesting that flavonoids probably contributed to the protective effect of Spondias mombin leaf.
- Subjects
CYANIDE poisoning; POTASSIUM cyanide; ELECTROLYTES; QUERCETIN; OXIDATION-reduction reaction; RATS; CHOLINERGIC receptors; TROPANES
- Publication
Science Progress, 2021, p1
- ISSN
0036-8504
- Publication type
Article
- DOI
10.1177/00368504211011866