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- Title
Amniotic fluid adhesion molecules during parturition at term.
- Authors
Kemp, Birgit; von Rango, Ulrike; Brehme, Anja; Rath, Werner
- Abstract
Aims: During term parturition a constant elevation of intercellular adhesion molecule (ICAM-1) as well as increases of endothelial leukocyte adhesion molecule (ELAM-1) and vascular cell adhesion molecule (VCAM-1) in the lower uterine segment and of ICAM-1 in fetal membranes were observed. We examined ELAM-1, ICAM-1 and VCAM-1 during normal term parturition to find out whether amniotic fluid adhesion molecules change accordingly. Methods: Amniotic fluid specimens of 35 patients undergoing cesarean section at term with various stages of cervical dilatation (<2 cm, n=11; 2–<4 cm, n=10; 4–6 cm, n=6; >6 cm, n=8) and different durations of labor (0 h, n=11; >0 h, n=24) were examined for ELAM-1, ICAM-1 and VCAM-1 by enzyme immunoassay. For statistical analysis one-way ANOVA (cervical dilatation) and unpaired t-test (duration of labor) were used (P<0.05). Results: Neither ELAM-1 nor VCAM-1 correlated with cervical dilatation or with the duration of labor. ICAM-1 showed a tendency to decline with the last phase of cervical dilatation (P=0.06) and a significant decline with labor (P=0.046). Conclusions: In contrast to adhesion molecules in the lower uterine segment amniotic fluid adhesion molecules ELAM-1 and VCAM-1 do not rise significantly during parturition. The decline of ICAM-1 may be due to a transfer to other compartments (i.e., lower uterine segment or retroplacental blood) thereby contributing to labor and cervical dilatation.
- Subjects
CELL adhesion molecules; LABOR (Obstetrics); AMNIOTIC liquid examination; CHILDBIRTH; ENZYME-linked immunosorbent assay; PHYSIOLOGY
- Publication
Journal of Perinatal Medicine, 2009, Vol 37, Issue 1, p28
- ISSN
0300-5577
- Publication type
Article
- DOI
10.1515/JPM.2009.002