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- Title
Structural basis for anticodon recognition by methionyl-tRNA synthetase.
- Authors
Nakanishi, Kotaro; Ogiso, Yuri; Nakama, Takashi; Fukai, Shuya; Nureki, Osamu
- Abstract
In the 2.7-Å resolution crystal structure of methionyl-tRNA synthetase (MetRS) in complex with tRNAMet and a methionyl-adenylate analog, the tRNA anticodon loop is distorted to form a triple-base stack comprising C34, A35 and A38. A tryptophan residue stacks on C34 to extend the triple-base stack. In addition, C34 forms Watson-Crick–type hydrogen bonds with Arg357. This structure resolves the longstanding question of how MetRS specifically recognizes tRNAMet.
- Subjects
TRANSFER RNA; LIGASES; TRYPTOPHAN; PROTEOMICS; MOLECULAR biology
- Publication
Nature Structural & Molecular Biology, 2005, Vol 12, Issue 10, p931
- ISSN
1545-9993
- Publication type
Article
- DOI
10.1038/nsmb988