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- Title
Unraveling chromatin organization.
- Authors
Eggleston, Angela K.
- Abstract
This article examines the chromatin compaction model. When linker DNA was cleaved by a restriction enzyme, the crosslinked species contained 5 or 6 nucleosomes, as would be predicted from the two start models but not from the solenoid model. Next, a 48-mer array of crosslinked particles was visualized by electron microscopy to follow the path of the fiber axis. Many fibers appeared as parallel rows of particles, which dissociated into single columns of particles when the linker DNA was cleaved. Higher resolution microscopy is be necessary to resolve further details.
- Subjects
CHROMATIN; CHROMOSOMES; NUCLEOPROTEINS; DNA; NUCLEIC acids; ELECTRON microscopy
- Publication
Nature Structural & Molecular Biology, 2005, Vol 12, Issue 1, p6
- ISSN
1545-9993
- Publication type
Article
- DOI
10.1038/nsmb0105-6