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- Title
A closed conformation for the Pol?catalytic cycle.
- Authors
Garcia-Diaz, Miguel; Bebenek, Katarzyna; Krahn, Joseph M.; Kunkel, Thomas A.; Pedersen, Lars C.
- Abstract
Pol?is a family X member believed to fill short gaps during DNA repair. Here we report crystal structures of Pol?representing three steps in filling a single-nucleotide gap. These structures indicate that, unlike other DNA polymerases, Pol?does not undergo large subdomain movements during catalysis, and they provide a clear characterization of the geometry and stereochemistry of the in-line nucleotidyl transfer reaction.
- Subjects
DNA repair; GENES; DNA; NUCLEIC acids; BIOCHEMICAL genetics; ANTIMUTAGENS
- Publication
Nature Structural & Molecular Biology, 2005, Vol 12, Issue 1, p97
- ISSN
1545-9993
- Publication type
Article
- DOI
10.1038/nsmb876