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- Title
Oxidative Divergent Bicyclizations of 1,n-Enynes through α-C( sp<sup>3</sup>)-H Functionalization of Alkyl Nitriles.
- Authors
Hu, Ming; Li, Meng; Tan, Fang ‐ Lin; Song, Ren ‐ Jie; Xie, Ye ‐ Xiang; Li, Jin ‐ Heng
- Abstract
A new, radical-mediated, divergent bicyclization of 1,n-enynes by α-C( sp3)-H oxidative functionalization of alkyl nitriles is described using the Sc(OTf)3 and Ag2O system. The reaction allows the selective functionalization of one or two C( sp3)−H bonds α to the nitrile group by both oxidants and the substitution effect co-controlled the divergent bicyclization reactions, and offers a step- and atom-economical access to diverse polycycles with broad substrate scope and high selectivity.
- Subjects
NITRILE derivatives; ENYNES; ALKYLATION; RING formation (Chemistry); OXIDIZING agents; HYDROGEN bonding
- Publication
Advanced Synthesis & Catalysis, 2017, Vol 359, Issue 1, p120
- ISSN
1615-4150
- Publication type
Article
- DOI
10.1002/adsc.201600926