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- Title
Dielectric and conductivity studies of stereo-selectively synthesized d- and l-nor-ephedrine.
- Authors
Jeya Rajendran, A.; Prabhu, M.; Eswara Moorthi, K.; Celine Rose, I.; Santhanaraj, D.; Sugandhi, K.; Radhika, S.
- Abstract
The stereo isomers, d- and l-phenyl propanolamine hydrochloride (nor-ephedrine) were stereo-selectively synthesized from benzaldehyde and nitroethane followed by catalytic reduction using hydrogen and Raney nickel. The nor-ephedrine was characterized by UV, IR, and LC/MS analysis. The purity of the synthesized nor-ephedrine hydrochlorides was analyzed using HPLC. Resolution of d- and l-isomer of PPA hydrochloride was carried out using the resolving agent, d-3-formyl-2,2,5,5-tetramethyl-1,3-thiazolidine-4-carboxylicacid. Optical rotation was found to be ±36°. The temperature and frequency dependence of dielectric constant, dielectric loss, and conductivity of d- and l-isomers of nor-ephedrine were studied over a range of frequency (50 Hz-5 MHz) and temperature (40-140 °C). It was found that d-isomer possesses higher dielectric constant and AC conductivity values compared to l-isomer. The band gap of 1.35 and 1.69 eV for d- and l-isomers, respectively, indicates that these two compounds behave as organic semiconductor materials.
- Subjects
DIELECTRICS; ELECTRIC conductivity; STEREOSELECTIVE reactions; EPHEDRINE; STEREOISOMERS; CHEMICAL synthesis
- Publication
Journal of Thermal Analysis & Calorimetry, 2015, Vol 119, Issue 1, p369
- ISSN
1388-6150
- Publication type
Article
- DOI
10.1007/s10973-014-4159-7