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- Title
Thermal characterization of indinavir sulfate using TG, DSC and DSC-photovisual.
- Authors
da Silva, Rosali Maria Ferreira; de Medeiros, Flávia Patricia Morais; Nascimento, T. G.; Macêdo, R. O.; Neto, P. J. R.
- Abstract
The object of the present work is to study the thermal characteristics of indinavir sulfate and to evaluate the quality of the raw materials. Indinavir A, B, C and reference samples were obtained from different suppliers and submitted to TG, DSC and DSC-photovisual analyses. TG/DTG curves indicated a desolvation and dehydration processes and were confirmed by DSC. According to the DSC curves the fusion took place at about 141–142°C for indinavir C and Reference sample B and about 146–149°C for the others. DSC-photovisual showed insoluble raw materials for indinavir C at 160°C. Indinavir sulfate is highly hygroscopic drug which requires attention during storage and manufacture by pharmaceutical industry.
- Subjects
QUALITY control; RAW materials; FUSION (Phase transformation); THERMAL analysis; ANALYTICAL chemistry; CALORIMETRY
- Publication
Journal of Thermal Analysis & Calorimetry, 2009, Vol 95, Issue 3, p965
- ISSN
1388-6150
- Publication type
Article
- DOI
10.1007/s10973-008-8912-7