We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Cytoprotective effects of catechin 7- O-β- D glucopyranoside against mitochondrial dysfunction damaged by streptozotocin in RINm5F cells.
- Authors
Kim, Ki Cheon; Kim, Jin Sook; Ah Kang, Kyoung; Kim, Jong Min; Won Hyun, Jin
- Abstract
The protective effects of catechin 7- O-β- D glucopyranoside (C7G) against streptozotocin (STZ)-induced mitochondrial damage in rat pancreatic β-cells (RINm5F) were investigated. A marked increase in mitochondrial reactive oxygen species (ROS) was observed in STZ-treated cells; this increase was restricted by C7G treatment. C7G also scavenged superoxide anions and hydroxyl radicals generated by xanthine/xanthine oxidase (xanthine/XO) and the Fenton reaction (FeSO4 + H2O2), respectively. C7G restored activity and expression of both mitochondrial manganese superoxide dismutase (MnSOD) and catalase (CAT), which were suppressed by STZ treatment. In addition, C7G prevented STZ-induced mitochondrial lipid peroxidation, protein carbonyl, and DNA base modification. C7G restored the loss of mitochondrial membrane potential (Δ ψ) that was disrupted by STZ treatment, and prevented cell death via inhibition of apoptosis. These results suggest that C7G has a protective effect against STZ-induced cell damage by its antioxidant effects and the attenuation of mitochondrial dysfunction. Copyright © 2010 John Wiley & Sons, Ltd.
- Publication
Cell Biochemistry & Function, 2010, Vol 28, Issue 8, p651
- ISSN
0263-6484
- Publication type
Article
- DOI
10.1002/cbf.1703