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- Title
Complementary displacement-encoded MRI for contrast-enhanced infarct detection and quantification of myocardial function in mice.
- Authors
Gilson, Wesley D.; Yang, Zequan; French, Brent A.; Epstein, Frederick H.
- Abstract
MRI is emerging as an important modality for assessing myocardial function in transgenic and knockout mouse models of cardiovascular disease, including myocardial infarction (MI). Displacement encoding with stimulated echoes (DENSE) measures myocardial motion at high spatial resolution using phase-reconstructed images. The current DENSE technique uses inversion recovery (IR) to suppress T1-relaxation artifacts; however, IR is ill-suited for contrast-enhanced infarct imaging in the heart, where multiple T1 values are observed. We have developed a modified DENSE method employing complementary acquisitions for T1-independent artifact suppression. With this technique, displacement and strain are measured in phase-reconstructed images, and contrast-enhanced regions of infarction are depicted in perfectly coregistered magnitude-reconstructed images. The displacement measurements and T1-weighted image contrast were validated with the use of a rotating phantom. Modified DENSE was performed in mice ( N = 9) before and after MI. Circumferential ( Ecc) and radial ( Err) strain were measured, and contrast-enhanced infarcted myocardium was detected by DENSE. At baseline, Ecc was −0.16 ± 0.01 and Err was 0.39 ± 0.07. After MI, Ecc was 0.04 ± 0.02 and Err was 0.03 ± 0.04 in infarcted regions, whereas Ecc was −0.12 ± 0.02 and Err was 0.38 ± 0.09 in noninfarcted regions. In vivo Ecc as determined by DENSE correlated well with Ecc obtained by conventional tag analysis (R = 0.90). Magn Reson Med 51:744-752, 2004. © 2004 Wiley-Liss, Inc.
- Publication
Magnetic Resonance in Medicine, 2004, Vol 51, Issue 4, p744
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.20003