We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Synthesis and Biological Properties of Enkephalin-like Peptides Containing Adamantylalanine in Position 4 and 5.
- Authors
Do, Kim Quang; Schwyzer, Robert
- Abstract
The syntheses of seven [ D-ala-2]-enkephalin analogues, H-Tyr-ala-Gly-X-Y, with X-Y = Phe-Ada-OH, Phe-ada-OH, Phe-Ada-NH2, Phe-ada-NH2, Ada-Leu-OH, Ada-Leu-NH2, and Ada-Ada-NH2 are described. The compounds with Y = Ada (= L-Ada) or ada (= D-Ada) show pronounced morphine-like activities in certain bioassays, whereas those with X = Ada were most inactive. The analogues were used to explore the influence of steric, electronic, and hydrophobic properties of the side chains of X and Y on opioid activity (see [14]).
- Publication
Helvetica Chimica Acta, 1981, Vol 64, Issue 7, p2084
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.19810640713