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- Title
Effects of plasma rich in growth factors (PRGF) on biomechanical properties of Achilles tendon repair.
- Authors
López-Nájera, Diego; Rubio-Zaragoza, Mónica; Sopena-Juncosa, Joaquín; Alentorn-Geli, Eduard; Cugat-Bertomeu, Ramón; Fernández-Sarmiento, J.; Domínguez-Pérez, Juan; García-Balletbó, Montserrat; Primo-Capella, Víctor; Carrillo-Poveda, José; Sopena-Juncosa, Joaquín J; Fernández-Sarmiento, J Andrés; Domínguez-Pérez, Juan M; Primo-Capella, Víctor J; Carrillo-Poveda, José M
- Abstract
<bold>Purpose: </bold>To assess the biomechanical effects of intra-tendinous injections of PRGF on the healing Achilles tendon after repair in a sheep model.<bold>Methods: </bold>Thirty sheep were randomly assigned into one of the six groups depending on the type of treatment received (PRGF or placebo) and survival time (2, 4 and 8 weeks). The Achilles tendon injury was repaired by suturing the tendinous edges employing a three-loop pulley pattern. A trans-articular external fixation system was then used for immobilization. The PRGF or placebo was administered on a weekly basis completing a maximum of three infiltrations. The force, section and tension values were compared between the operated and healthy Achilles tendons across all groups.<bold>Results: </bold>The PRGF-treated tendons had higher force at 8 weeks compared with the placebo group (p = 0.007). Between 2 and 4 weeks, a significant increase in force in both the PRGF-treated tendon (p = 0.0027) and placebo group (p = 0.0095) occurred. No significant differences were found for section ratio between PRGF-treated tendons and the placebo group for any of the time periods evaluated. At 2 weeks, PRGF-treated tendons had higher tension ratio compared with placebo group tendons (p = 0.0143). Both PRGF and placebo treatments significantly improved the force (p < 0.001 and p = 0.0095, respectively) and tension (p = 0.009 and p = 0.0039, respectively) ratios at 8 weeks compared with 2 weeks.<bold>Conclusion: </bold>The application of PRGF increases Achilles tendon repair strength at 8 weeks compared with the use of placebo. The use of PRGF does not modify section and tension ratios compared with placebo at 8 weeks. The tension ratio progressively increases between 2 and 8 weeks compared with the placebo.
- Subjects
ACHILLES tendon injury treatment; PLACEBOS; FRACTURE fixation; MUSCLE strength measurement; BIOMECHANICS; ACHILLES tendon; ACHILLES tendon injuries; GROWTH factors; TENDON injury treatment; ANIMALS; BLOOD plasma; INJECTIONS; KINEMATICS; ORTHOPEDIC surgery; STATISTICAL sampling; SHEEP; WOUND healing; SURGERY; THERAPEUTICS
- Publication
Knee Surgery, Sports Traumatology, Arthroscopy, 2016, Vol 24, Issue 12, p3997
- ISSN
0942-2056
- Publication type
journal article
- DOI
10.1007/s00167-015-3725-2