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- Title
Contribution of Mössbauer spectroscopy to the investigation of Fe/S biogenesis.
- Authors
Garcia-Serres, Ricardo; Clémancey, Martin; Latour, Jean-Marc; Blondin, Geneviève
- Abstract
Abstract: Fe/S cluster biogenesis involves a complex machinery comprising several mitochondrial and cytosolic proteins. Fe/S cluster biosynthesis is closely intertwined with iron trafficking in the cell. Defects in Fe/S cluster elaboration result in severe diseases such as Friedreich ataxia. Deciphering this machinery is a challenge for the scientific community. Because iron is a key player, 57Fe-Mössbauer spectroscopy is especially appropriate for the characterization of Fe species and monitoring the iron distribution. This minireview intends to illustrate how Mössbauer spectroscopy contributes to unravel steps in Fe/S cluster biogenesis. Studies were performed on isolated proteins that may be present in multiple protein complexes. Since a few decades, Mössbauer spectroscopy was also performed on whole cells or on isolated compartments such as mitochondria and vacuoles, affording an overview of the iron trafficking.Graphical abstract: This minireview aims at presenting selected applications of 57Fe-Mössbauer spectroscopy to Fe/S cluster biogenesis<graphic></graphic>
- Subjects
MITOCHONDRIAL proteins; BIOSYNTHESIS; SACCHAROMYCES cerevisiae; IRON-sulfur proteins; ELECTRON paramagnetic resonance spectroscopy; NUCLEAR magnetic resonance spectroscopy; IRON oxides
- Publication
Journal of Biological Inorganic Chemistry (JBIC), 2018, Vol 23, Issue 4, p635
- ISSN
0949-8257
- Publication type
Article
- DOI
10.1007/s00775-018-1534-z