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- Title
Evolution of MHC-DRBclass II polymorphism in the genusApodemusand a comparison ofDRBsequences within the family Muridae (Mammalia: Rodentia).
- Authors
Musolf, Kerstin; Meyer-Lucht, Yvonne; Sommer, Simone
- Abstract
Allelic diversity at major histocompatibility complex (MHC) genes is thought to be maintained by balancing selection over long periods of time, even across multiple speciation events. Trans-species sharing of MHC alleles among genera has been supported by many studies on mammals and fish, but in rodents, the results are ambiguous. We investigated natural levels of MHC-DRBvariability and evolutionary processes in the wood mouse (Apodemus sylvaticus) and the yellow-necked mouse (Apodemus flavicollis), which are common, sympatric murid rodents in European forests. Using single-strand conformation polymorphism analysis and DNA sequencing, 38DRBexon 2 alleles were detected among 162A. sylvaticusfrom nine different locations in Germany and Switzerland, and 15DRBexon 2 alleles were detected among 60A. flavicollisfrom three different locations in northern Germany. There was evidence for balancing selection in both species. Phylogenetic analysis, including additional murid taxa, showed that theDRBexon 2 sequences did not separate according to species, consistent with trans-species evolution of the MHC in these taxa.
- Subjects
MAJOR histocompatibility complex; IMMUNOGENETICS; GENETIC polymorphisms; MURIDAE; APODEMUS sylvaticus
- Publication
Immunogenetics, 2004, Vol 56, Issue 6, p420
- ISSN
0093-7711
- Publication type
Article
- DOI
10.1007/s00251-004-0715-9