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- Title
Donanemab detects a minor fraction of amyloid-β plaques in post-mortem brain tissue of patients with Alzheimer's disease and Down syndrome.
- Authors
Bouter, Yvonne; Liekefeld, Hendrik; Pichlo, Steffen; Westhoff, Anna Celine; Fenn, Lydia; Bakrania, Preeti; Bayer, Thomas A.
- Abstract
In temporal cortex brain sections of AD and Down syndrome cases, both pan-A pE3 antibody 1-57 and donanemab detected only a fraction of plaques compared to the pan-A antibody 2431-1 (Fig. Donanemab detects a minor fraction of amyloid- plaques in post-mortem brain tissue of patients with Alzheimer's disease and Down syndrome Saido et al I . i [[12]] demonstrated for the first time that A pE3 production and retention is an early and critical event in senile plaque formation in AD and Down syndrome patients. Importantly, the deposition of A pE3 was reported to be directly linked with hyperphosphorylated tau and neuropathological staging of AD [[7]] as well as in related mouse models [[9]], clearly supporting its role as a potential drug target against AD.
- Subjects
ALZHEIMER'S patients; DOWN syndrome; IMMUNOGLOBULINS
- Publication
Acta Neuropathologica, 2022, Vol 143, Issue 5, p601
- ISSN
0001-6322
- Publication type
Article
- DOI
10.1007/s00401-022-02418-3