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- Title
Self-Report Daily Life Activity as a Prognostic Marker of Idiopathic Pulmonary Fibrosis.
- Authors
Leuchte, Hanno H.; Mernitz, Philip; Baezner, Carlos; Baumgartner, Rainer a.; von Wulffen, Werner; Neurohr, Claus; Behr, Juergen
- Abstract
Background: Idiopathic pulmonary fibrosis (IPF) is a progressive disease, leading to substantial physical impairment. The distance walked in 6 min (6MWD) is a measure of exercise tolerance and is of prognostic relevance in IPF. While 6MWD is a punctual measurement which may not be representative, self-reported daily life activity may represent the patients' functional capacity more globally even in less severe affected patients. Objectives: We evaluated and characterized a simple classification system based on the patients' self-reported daily activity and analyzed if this would add significantly to the prognostic information of the 6MWD alone in IPF patients. Methods: Daily life activity was assessed in IPF (n = 156) patients with standardized questions and categorized in activity classes (AC I-IV), comprising the less severe impaired in AC I and II. The 6MWD was also assessed. Results: ACs were related to the lung functional impairment and inversely correlated to the 6MWD. Thirty-two patients were in AC I/II, 98 in AC III and 26 patients in AC IV. Thirty-seven (23.7%) patients died during a median follow-up of 14.9 months, comprising 1 patient in AC I/II. In addition, a 6MWD <470 m predicted mortality. Combining AC I/II and a 6MWD >470 m identified a subgroup of patients with favorable outcome. Conclusions: AC is a novel scoring system which can easily be obtained and correlates with lung functional and physical impairments as well as mortality. Moreover, AC adds prognostic information to the 6MWD. © 2015 S. Karger AG, Basel
- Subjects
CLASSIFICATION; LIFE skills; LONGITUDINAL method; PATIENTS; QUESTIONNAIRES; SELF-evaluation; SURVIVAL analysis (Biometry); ACTIVITIES of daily living; SEVERITY of illness index; PHYSICAL activity; FUNCTIONAL assessment; IDIOPATHIC pulmonary fibrosis; DESCRIPTIVE statistics; PROGNOSIS
- Publication
Respiration, 2015, Vol 90, Issue 6, p460
- ISSN
0025-7931
- Publication type
Article
- DOI
10.1159/000441302