We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Cancer-related inflammation.
- Authors
Mantovani, Alberto; Allavena, Paola; Sica, Antonio; Balkwill, Frances
- Abstract
The mediators and cellular effectors of inflammation are important constituents of the local environment of tumours. In some types of cancer, inflammatory conditions are present before a malignant change occurs. Conversely, in other types of cancer, an oncogenic change induces an inflammatory microenvironment that promotes the development of tumours. Regardless of its origin, 'smouldering' inflammation in the tumour microenvironment has many tumour-promoting effects. It aids in the proliferation and survival of malignant cells, promotes angiogenesis and metastasis, subverts adaptive immune responses, and alters responses to hormones and chemotherapeutic agents. The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.
- Subjects
INFLAMMATION; TUMORS; CANCER diagnosis; CANCER treatment; CANCER cells; NEOVASCULARIZATION; METASTASIS; IMMUNE response; HORMONES; DRUG therapy
- Publication
Nature, 2008, Vol 454, Issue 7203, p436
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/nature07205