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- Title
Polymorphisms in XPD and hOGGI and Prostate Cancer Risk: A Meta-Analysis.
- Authors
Shimiao Zhu; Hui Zhang; Yang Tang; Jianmin Wang
- Abstract
Objective: To examine the association between XPD and hOGGI polymorphisms and prostate cancer (PCa) suscepti-bility. Methods: A comprehensive search was conducted to identify all case-control studies on the relationship between XPD and hOGGI polymorphisms and PCa risk. Odds ratios (ORs) were used to investigate the strength of the associa-tions. Results: A total of 15 case-control studies including 5,765 cases and 6,270 controls were eligible for the meta-analyses. For XPD Asp312Asn, no evidence indicated that in-dividuals carrying 312Asn had an increased risk of PCa. In subgroup analyses, Asp312Asn polymorphism was associ-ated with PCa risk in Asian populations [OR = 2.09 and 95% CI = 1.39-3.14 for Asn/Asn vs. Asp/Asp; OR = 1.49 and 95% CI = 1.12-1.98 for (Asn/Asn+Asn/Asp) vs. Asp/Asp]. For XPD Lys751 Gin, the individuals with 751Gln did not have increased PCa risk compared with those with 751Arg, and no asso-ciation was found in the subgroup analyses. For hOGGI Ser326Cys, no significant association between the polymor-phism and PCa risk was observed in the overall analysis. However, Ser326Cys was significantly associated with PCa risk under homologous contrast in Caucasians and Asians. Conclusions: XPD Asp312Asn polymorphism is associated with PCa risk in Asians and hOGGI Ser326Cys polymorphism is associated with PCa risk in Caucasians and Asians.
- Subjects
PROSTATE cancer risk factors; GENETIC polymorphisms; DISEASE susceptibility; XERODERMA pigmentosum; META-analysis; MEDICAL statistics
- Publication
Urologia Internationalis, 2012, Vol 89, Issue 2, p233
- ISSN
0042-1138
- Publication type
Article
- DOI
10.1159/000339603