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- Title
Hypothesis for the Mechanism of Elevated Serum Copper in Cancer Patients.
- Authors
Fisher, G.L.; Shifrine, M.
- Abstract
Neoplastic growths seem to interfere with normal processes regulating the serum level of ceruloplasmin, a copper-containing oxidase, which accounts for 96% of serum copper. Normal catabolism of ceruloplasmin in the liver follows desialylation. However, in patients with tumors, ceruloplasmin may be resialylated at the tumor cell surface or in peripheral blood. Decreased catabolism due to resialylation of asialo-ceruloplasmin could account for the increased concentration of serum copper noted in patients with neoplasia. Copyright © 1978 S. Karger AG, Basel
- Publication
Oncology, 1978, Vol 35, Issue 1, p22
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000225249