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- Title
Speckle optical monitoring of blood microcirculation for different types of treatment of the vascular system.
- Authors
Khludeyev, I.; Tserakh, A.; Smirnov, A.; Dick, S.; Zorina, V.
- Abstract
We have studied correlations between the changes in the characteristics of the speckle field (spectral power, bandpass coefficient) and variations in blood microcirculation in different areas of the skin for different types of treatment. We have established that the properties of the photosensitizer have a considerable effect on the mechanism and dynamics of development of photosensitized damage to blood vessels. Comparison of photosensitized disturbances of the blood microcirculation when using chlorin e and the dimethyl ester of chlorin e showed that the dimethylester of chlorin e is a more effective sensitizer for selective damage to the vascular system of the target tissue in photodynamic treatment. With the goal of developing a noninvasive speckle optical method for monitoring the status of the vascular system of the skin, we have designed a Speckle Scan device, the operation of which is based on analysis of the parameters of the dynamic speckle field created by reflection and scattering of the probing laser radiation by biological tissues.
- Subjects
SPECKLE interferometry; OPTICAL images; MICROCIRCULATION; TREATMENT of vascular diseases; LASER beams; PHOTODYNAMIC therapy; SKIN blood-vessels
- Publication
Journal of Applied Spectroscopy, 2013, Vol 80, Issue 2, p299
- ISSN
0021-9037
- Publication type
Article
- DOI
10.1007/s10812-013-9762-z