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- Title
Is birth a critical period in the pathogenesis of autism spectrum disorders?
- Authors
Ben-Ari, Yehezkel
- Abstract
Birth is associated with a neuroprotective, oxytocin-mediated abrupt excitatory-to-inhibitory GABA shift that is abolished in autism, and its restoration attenuates the disorder in offspring. In this Opinion article, I discuss the links between birth-related stressful mechanisms, persistent excitatory GABA actions, perturbed network oscillations and autism. I propose that birth (parturition) is a critical period that confirms, attenuates or aggravates the deleterious effects of intrauterine genetic or environmental insults.
- Subjects
AUTISM spectrum disorders; GABA; PERVASIVE child development disorders; AMINO acid neurotransmitters; OXYTOCIN
- Publication
Nature Reviews Neuroscience, 2015, Vol 16, Issue 8, p498
- ISSN
1471-003X
- Publication type
Article
- DOI
10.1038/nrn3956