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- Title
Juxtamembrane autoinhibition in receptor tyrosine kinases.
- Authors
Hubbard, Stevan R.
- Abstract
Receptor tyrosine kinases are essential mediators of cell growth, differentiation, migration and metabolism. Accordingly, their catalytic activity is tightly regulated by several mechanisms including autoinhibition. Recent structural studies, together with biochemical experiments, are now unravelling the molecular mechanisms by which the juxtamembrane region (between the transmembrane helix and the cytoplasmic kinase domain) negatively regulates catalytic activity in various receptor tyrosine kinases.
- Subjects
PROTEIN-tyrosine kinases; PROTEIN kinases; CELL differentiation; CELL migration; CELL metabolism
- Publication
Nature Reviews Molecular Cell Biology, 2004, Vol 5, Issue 6, p464
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm1399