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- Title
Calcium: Regulation of cell death: the calcium-apoptosis link.
- Authors
Orrenius, Sten; Zhivotovsky, Boris; Nicotera, Pierluigi
- Abstract
To live or to die? This crucial question eloquently reflects the dual role of Ca2+ in living organisms - survival factor or ruthless killer. It has long been known that Ca2+ signals govern a host of vital cell functions and so are necessary for cell survival. However, more recently it has become clear that cellular Ca2+ overload, or perturbation of intracellular Ca2+ compartmentalization, can cause cytotoxicity and trigger either apoptotic or necrotic cell death.
- Subjects
APOPTOSIS; CALCIUM; CELL-mediated cytotoxicity; HOMEOSTASIS; CELL compartmentation
- Publication
Nature Reviews Molecular Cell Biology, 2003, Vol 4, Issue 7, p552
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm1150