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- Title
Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response.
- Authors
King, Katherine Y.; Goodell, Margaret A.
- Abstract
Cells of the innate and adaptive immune systems are the progeny of a variety of haematopoietic precursors, the most primitive of which is the haematopoietic stem cell. Haematopoietic stem cells have been thought of generally as dormant cells that are only called upon to divide under extreme conditions, such as bone marrow ablation through radiation or chemotherapy. However, recent studies suggest that haematopoietic stem cells respond directly and immediately to infections and inflammatory signals. In this Review, we summarize the current literature regarding the effects of infection on haematopoietic stem cell function and how these effects may have a pivotal role in directing the immune response from the bone marrow.
- Subjects
HEMATOPOIETIC stem cells; BONE marrow diseases; DRUG therapy; IMMUNE response; ABLATION techniques; THERAPEUTICS; BONE marrow; CELL differentiation; CELL receptors; CELLULAR signal transduction; CYTOKINES; GROWTH factors; HOMEOSTASIS; IMMUNITY; IMMUNOPHENOTYPING; INFLAMMATION; RESEARCH funding
- Publication
Nature Reviews Immunology, 2011, Vol 11, Issue 10, p685
- ISSN
1474-1733
- Publication type
journal article
- DOI
10.1038/nri3062