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- Title
Nutrient sensing and inflammation in metabolic diseases.
- Authors
Hotamisligil, Gökhan S.; Erbay, Ebru; Hotamisligil, Gökhan S
- Abstract
The proper functioning of the pathways that are involved in the sensing and management of nutrients is central to metabolic homeostasis and is therefore among the most fundamental requirements for survival. Metabolic systems are integrated with pathogen-sensing and immune responses, and these pathways are evolutionarily conserved. This close functional and molecular integration of the immune and metabolic systems is emerging as a crucial homeostatic mechanism, the dysfunction of which underlies many chronic metabolic diseases, including type 2 diabetes and atherosclerosis. In this Review we provide an overview of several important networks that sense and manage nutrients and discuss how they integrate with immune and inflammatory pathways to influence the physiological and pathological metabolic states in the body.
- Subjects
METABOLIC disorders; IMMUNE response; ATHEROSCLEROSIS; CHRONIC diseases; DIABETES; INFLAMMATION; CELLULAR signal transduction; COMPARATIVE studies; ENERGY metabolism; HOMEOSTASIS; RESEARCH methodology; MEDICAL cooperation; RESEARCH; EVALUATION research; NUTRITIONAL status
- Publication
Nature Reviews Immunology, 2008, Vol 8, Issue 12, p923
- ISSN
1474-1733
- Publication type
journal article
- DOI
10.1038/nri2449