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- Title
Autoimmune Encephalitis: Report of Two Pediatric Cases.
- Authors
Tavasoli, Azita; Shooshtari, Mitra Hakim; Parvini, Behnaz
- Abstract
Introduction: Autoimmune encephalitis (AIE) with neural cell autoantibodies is a treatable category of non-viral encephalitis in children and adolescents which presents with neuropsychiatric manifestations. Anti-N-methyl- D-aspartate receptor encephalitis, the most common identified type of AIE, is more frequent than individual viral encephalitis in young patients. Early diagnosis and treatment of the disease have been associated with improvement in the majority of patients. Case Report: we report two pediatric cases with acute neuropsychiatric presentations in whom the diagnosis of AIE was proved based on the cerebrospinal fluid (CSF) antineuronal antibodies in one and on clinical and paraclinical grounds in another seronegative patient. Immunotherapy in both patients resulted in improvement. No underlying tumor was found in patients. Pediatricians should be aware of manifestations, investigations, and treatment of AIE and consider it as the differential diagnosis of encephalitis.
- Subjects
AUTOANTIBODIES; VIRAL encephalitis; ANTI-NMDA receptor encephalitis; CEREBROSPINAL fluid examination; ENCEPHALITIS; CEREBROSPINAL fluid; THERAPEUTICS
- Publication
Journal of Kerman University of Medical Sciences, 2021, Vol 28, Issue 4, p404
- ISSN
1023-9510
- Publication type
Article
- DOI
10.22062/JKMU.2021.91722