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- Title
High-purity magnesium pin enhances bone consolidation in distraction osteogenesis model through activation of the VHL/HIF-1α/VEGF signaling.
- Authors
Hamushan, Musha; Cai, Weijie; Zhang, Yubo; Lou, Tengfei; Zhang, Shaoxiang; Zhang, Xiaonong; Cheng, Pengfei; Zhao, Changli; Han, Pei
- Abstract
Distraction osteogenesis has widespread clinical use in the treatment of large bone defects. Nonetheless, the prolonged consolidation period carries the risk of complications. Magnesium-based materials have been shown to promote bone regeneration in fracture healing both in vitro and in vivo. Here, we investigated whether high-purity magnesium could enhance bone formation in distraction osteogenesis. High-purity magnesium pins were placed into the medullary cavity in the rat distraction osteogenesis model. Results showed that the bone volume/total tissue volume, bone mineral density, and mechanical properties of new callus were significantly higher in the high-purity magnesium group compared to stainless steel and control group (p < 0.01). Histological analyses confirmed improved bone consolidation and vascularization in high-purity magnesium group. Further, polymerase chain reaction-array investigation, Western blot, and immunohistochemical results found that vascular endothelial growth factor and hypoxia inducible factor-1α were highly expressed in the high-purity magnesium group, while Von Hippel–Lindau protein was the opposite (p < 0.01). In conclusion, high-purity magnesium implants have the potential to enhance angiogenesis and bone consolidation in the distraction osteogenesis application, and this process might be via the regulation of Von Hippel–Lindau/hypoxia inducible factor-1α/vascular endothelial growth factor signaling.
- Subjects
BONES; VASCULAR endothelial growth factors; BONE density; ENDOTHELIAL growth factors; MAGNESIUM; NARINGIN; HYPOXIA-inducible factor 1; TERIPARATIDE
- Publication
Journal of Biomaterials Applications, 2020, Vol 35, Issue 2, p224
- ISSN
0885-3282
- Publication type
Article
- DOI
10.1177/0885328220928550