We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Frequency of CYP1A1*2A polymorphisms and deletion of the GSMT1 gene in a Peruvian mestizo population.
- Authors
Tito Alvarado, Angel; María Muñoz, Ana; Saravia Bartra, María; Valderrama-Wong, Milton; González, Daniela; Abel Quiñones, Luis; Varela, Nelson; Rocío Bendezú, María; Antonio García, Jorge; Loja-Herrera, Berta
- Abstract
The polymorphic variants of CYP1A1 and the deletion of GSTM1 are present in the Peruvian mestizo population. Wild type and mutated genotypes (WT/*2A and *2A/ *2A) were identified, whose allele frequencies are 0.31 (T allele) and 0.69 (C allele), respectively; 53% with wild type GSTM1 (+) and 47% with null GSTM1. The frequency in Iquiteño emigrants was 0.72 CYP1A1*2A and 25% GSTM1 (-); from Lima 0.67 CYP1A1*2A and 33% of GSTM1 (-). The Hardy-Weinberg equilibrium test for the studied population showed that both frequencies are out of balance, p > .05. The presence of the risk allele of the CYP1A1*2A polymorphism and the deletion in the GSTM1 gene are high, which could be indicative of a phase I and II metabolic imbalance in this group of Peruvian populations, with potential risks of activating agents procarcinogens thus affecting the incidence of tumor pathologies with an environmental component.
- Subjects
GENETIC polymorphisms; GENOTYPES; PATHOLOGY; TUMORS; PERUVIANS
- Publication
Pharmacia (0428-0296), 2021, Vol 68, Issue 4, p747
- ISSN
0428-0296
- Publication type
Article
- DOI
10.3897/pharmacia.68.e71621