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- Title
GLUCOCORTICOID EXCESS AND FETAL DEVELOPMENT IN WHITE WISTAR RATS.
- Authors
Kis, Erika
- Abstract
Despite the clear physiological importance of endogenous glucocorticoids during development, there is a multitude of data to show that exposure to excess exogenous glucocorticoids during pregnancy correlates with reduced birth weight and adverse outcomes in the offspring, especially if glucocorticoids are administered during late gestation when growth is accelerating and presumably thus most susceptible to the catabolic effects of. As resulted from our preliminary experiments a short-term epicutaneous treatment with Fluocinolon-acetonid N in various age groups of rats induces structural and ultrastructural modifications of some organs accompanied by several biochemical disorders. In recent studies elsewhere we have reported that short-term and long-term epicutaneouse applications of halogenated glucocorticosteroids in pregnant rats induced changes of thymus oxidative status of dams and newborn animals. Starting from the above observations we investigated the relationship between fetal brain development and fetal body weight evolution under glucocorticoid excess, induced by Fluocinolon N ointment, administered to female rats during gestation. Our results indicate that glucocorticoid excess in prenatal life modifies fetus development and might contribute to metabolic disorders in newborn rats reflected by decrease of body weight.
- Subjects
GLUCOCORTICOID regulation; FETAL brain abnormalities; PREGNANCY in animals; BODY weight; METABOLIC disorders in animals; VETERINARY therapeutics
- Publication
Annals of the Romanian Society for Cell Biology, 2012, Vol 17, Issue 2, p82
- ISSN
2067-3019
- Publication type
Article