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- Title
隐绿原酸对H9N2-AIV致小鼠肺损伤的免疫调节和抗氧化效果.
- Authors
张昕; 张铭; 何宏轩; 胡延春
- Abstract
To investigate the effect of cryptochlorogenic acid(4-CQA)on lung injury and recovery in mice infected with avian influenza H9N2 virus, ninety SPF KM mice(6-8 weeks old)were randomly divided into H9N2 group,H9N2+4-CQA group, control group and 4-CQA group. Then H9N2-AIV was used to induce lung injury and received 4-CQA intragastric administration respectively in mice. The lung histopathlogy changes, the lung index and spleen index, and the contents of malondialdehyde (MDA),total superoxide dismutase (T-SOD) and myeloperoxidase (MPO) in the lung tissue homogenate, and the ratio of T cell subgroups (CD4+、CD8+、CD4+/CD8+) were observed. The results showed that the group of H9N2 presented depression and shortness of breath; lung index increased and spleen index decreased; histopathological manifestations of lung were alveolar atrophy, alveolar septal thickening and local lung consolidation; CD4+/CD8+ ratio of T lymphocyte subsets decreased significantly (P<0.05), activity of T-SOD decreased significantly, content of MDA increased significantly, and activity of MPO increased significantly (P<0.05). After 4-CQA treatment, lung index decreased and spleen index increased; lung histopathological damage was alleviated; CD4+/CD8+ ratio of T cell subgroups was significantly increased (P<0.05); T-SOD and MPO activity in lung were significantly increased and the content of MDA was significantly decreased (P<0.05). It was concluded that 4-CQA can alleviate the lung injury induced by avian influenza H9N2 virus by maintaining immune balance and reducing oxidative damage.
- Publication
Acta Agriculturae Zhejiangensis, 2022, Vol 34, Issue 1, p33
- ISSN
1004-1524
- Publication type
Article
- DOI
10.3969/j.issn.1004-1524.2022.01.05