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- Title
肿瘤相关巨噬细胞在胆管细胞癌中的作用.
- Authors
韩品盛; 杨龙; 崔涛; 张雅敏
- Abstract
Cholangiocarcinoma (CCA) is a highly malignant biliary tumor with strong invasion and poor prognosis and is insensitive to radiotherapy and chemotherapy. Tumor-associated macrophage (TAM) is an important component of the tumor microenvironment. CCA cells recruit TAM into tumor tissue by releasing cytokines and polarize them into M2 TAM, which promotes the progression of CCA through various mechanisms such as assisting immune escape, promoting tumor cell proliferation, regulating angiogenesis, promoting tumor metastasis, and mediating immune resistance. As an emerging target of tumor immunotherapy, TAM provides new ideas for targeted therapy for CCA. This article reviews the mechanisms of TAM in promoting the progression of CCA and immunotherapy targeting TAM in recent years.
- Publication
Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi, 2023, Vol 39, Issue 2, p469
- ISSN
1001-5256
- Publication type
Article
- DOI
10.3969/j.issn.1001-5256.2023.02.035