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- Title
Assessing the presence of oligoclonal IgM bands as a prognostic biomarker of cognitive decline in the early stages of multiple sclerosis.
- Authors
Coll‐Martinez, Clàudia; Quintana, Ester; Salavedra‐Pont, Judit; Buxó, Maria; González‐del‐Rio, Marina; Gómez, Immaculada; Muñoz‐San Martín, María; Villar, Luisa María; Álvarez‐Bravo, Gary; Robles‐Cedeño, René; Ramió‐Torrentà, Lluís; Gich, Jordi
- Abstract
Background: An association has been found between the presence of lipid‐specific oligoclonal IgM bands (LS‐OCMB) in cerebrospinal fluid and a more severe clinical multiple sclerosis course. Objective: To investigate lipid‐specific oligoclonal IgM bands as a prognostic biomarker of cognitive impairment in the early stages of multiple sclerosis. Methods: Forty‐four patients underwent neuropsychological assessment at baseline and 4 years. Cognitive performance at follow‐up was compared adjusting by age, education, anxiety–depression, and baseline performance. Results: LS‐OCMB+ patients only performed worse for Long‐Term Storage in the Selective Reminding Test (p =.018). Conclusion: There are no remarkable cognitive differences between LS‐OCMB– and LS‐OCMB+ patients in the early stages of MS. Although an association has been reported between the presence of lipid‐specific oligoclonal IgM bands (LS‐OCMB) in cerebrospinal fluid and a more severe clinical multiple sclerosis course, no remarkable cognitive differences were found in this study between LS‐OCMB– and LS‐OCMB+ patients in the early stages of MS.
- Subjects
COGNITION disorders; MULTIPLE sclerosis; BIOMARKERS; COGNITIVE ability; NEUROPSYCHOLOGICAL tests
- Publication
Brain & Behavior, 2021, Vol 11, Issue 12, p1
- ISSN
2162-3279
- Publication type
Article
- DOI
10.1002/brb3.2405