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- Title
Application of the Simplex Lattice Design Method in Optimizing the Formula of Kopasanda Leaf Extract Chewable Tablets.
- Authors
Stiani, Sofi Nurmay; Pertiwi, Meila; Insani, Nurul
- Abstract
Introduction: Kopasanda plant (Chromolaena odorata L.) is a plant that lives in tropical and sub-tropical areas. The flavonoid content in kopasanda plants functions as an antioxidant, counteracts free radicals and as antihypercholesterolemia. This study aimed to determine the effect of the combination of excipients on the physical properties of tablets and obtain the optimum formula of the combination of mannitol and lactose in chewable tablets. Methods: The method of this research is experimental, including material collection, preparation (F1 = 50%:50%, F2 = 0%:100%, F3 = 75%:25%, F4 = 100%:0%, F5 = 25%:75%), granule quality evaluation and tablet physical properties evaluation. To meet these criteria, materials were combined and analyzed using the simplex lattice design method. Results: Based on the results of the study, it shows that the evaluation of granule physical properties (flow time, angle of repose, and settling) of the five formulas has met the requirements. In terms of physical quality evaluation of tablets including weight uniformity test, size uniformity, hardness, friability, disintegration time, hedonic and taste responses showed that the five formulas produced tablets with good physical quality and met the requirements. Conclusion: The test results of flow time, hardness, disintegration time and taste responses have a significant effect on all formulas. The optimum formula for chewable tablets with the proportion of mannitol (0%) and lactose (100%) obtained a desirability value of 0.838.
- Subjects
CHROMOLAENA odorata; FLAVONOIDS; FREE radicals; MANNITOL; LACTOSE
- Publication
Malaysian Journal of Medicine & Health Sciences, 2024, Vol 20, p111
- ISSN
1675-8544
- Publication type
Article