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- Title
The Musculoskeletal System in Health and Disease: A Multidisciplinary Approach to Find Better Treatments for Musculoskeletal Disease.
- Authors
Gartland, Alison
- Abstract
Musculoskeletal diseases are one of the world’s leading causes of disability with 1.71 billion people having musculoskeletal conditions worldwide, leading to significant socio-economic cost and poor quality of life across the globe. Musculoskeletal diseases include rare congenital diseases such as Osteogenesis imperfecta and Hypophosphatasia (HPP); common, often epigenetic, diseases such as osteoarthritis and osteoporosis; and cancers that affect the bone both directly such as osteosarcoma and Ewing’s sarcoma primary bone cancers, and those cancer that metastasis to bone such as breast and prostate cancer. The focus of the Gartland Lab is understanding the basic cellular and molecular mechanisms responsible for these musculoskeletal diseases. Our Research involves a multidisciplinary approach using clinically relevant in vitro and in vivo models of disease, physiological experimentation, and state of the art molecular techniques. This talk will give an overview of the projects past and present to illustrate how our approach and our research findings are moving towards better treatments for patients with Musculoskeletal diseases.
- Subjects
MUSCULOSKELETAL system diseases; THERAPEUTICS; EWING'S sarcoma; CONGENITAL disorders; STERNUM; PROSTATE cancer
- Publication
Malaysian Journal of Medicine & Health Sciences, 2024, Vol 20, p2
- ISSN
1675-8544
- Publication type
Article