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- Title
Anti-Inflammatory Potential of Rutin Isolated from Physalis angulata: A Promising Source for Therapeutic Intervention.
- Authors
M. Bakri, Nur Syafika Aina; Abdullah, Fauziah; Yunos, Nurhanan Murni; Pisar, Mazura Md.; Sallehudin, Nor Jannah
- Abstract
Introduction: Physalis angulata, an indigenous herb belonging to the Solanaceae family, has been recognised for its medicinal significance and is commonly found in tropical and subtropical regions. This study aimed to evaluate the anti-inflammatory activity of rutin, a flavonoid found in P. angulata. Method: A phytochemical analysis of the water fraction of the entire plant was conducted using chromatographic techniques, leading to the isolation and identification of rutin. The compound's structure was established through the interpretation of NMR spectroscopic data. The anti-inflammatory potential of the isolated rutin was assessed through various enzymatic inhibitory assays, including lipoxygenase, hyaluronidase, protein denaturation, xanthine oxidase and elastase. These enzymes are known to play essential roles in the inflammatory processes associated with various diseases. Results: The assayed compound exhibited promising anti-inflammatory properties with moderate inhibitory activity against elastase, lipoxygenase and xanthine oxidase but weakest in hyaluronidase inhibitory activity. Conclusion: We concluded that the tested flavonoid rutin has the potential to be a candidate for anti-inflammatory agents for the prevention and treatment of numerous diseases, that are caused by complex inflammatory processes.
- Subjects
RUTIN; PHYSALIS; XANTHINE oxidase; DENATURATION of proteins; FLAVONOIDS
- Publication
Malaysian Journal of Medicine & Health Sciences, 2024, Vol 20, p74
- ISSN
1675-8544
- Publication type
Article