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- Title
Effect of synbiotic supplementation in children and adolescents with cystic fibrosis: a randomized controlled clinical trial.
- Authors
de Freitas, Maiara Brusco; Moreira, Emilia Addison Machado; Oliveira, Diane de Lima; Tomio, Camila; da Rosa, Julia Salvan; Moreno, Yara Maria Franco; Barbosa, Eliana; Ludwig Neto, Norberto; Buccigrossi, Vittoria; Guarino, Alfredo; Fröde, Tânia Silvia
- Abstract
<bold>Background/objectives: </bold>Cystic fibrosis (CF) is characterized by excessive activation of immune processes. The aim of this study was to evaluate the effect of synbiotic supplementation on the inflammatory response in children/adolescents with CF.<bold>Subjects/methods: </bold>A randomized, placebo-controlled, double-blind, clinical-trial was conducted with control group (CG, n = 17), placebo-CF-group (PCFG, n = 19), synbiotic CF-group (SCFG, n = 22), PCFG negative (n = 8) and positive (n = 11) bacteriology, and SCFG negative (n = 12) and positive (n = 10) bacteriology. Markers of lung function (FEV1), nutritional status [body mass index-for age (BMI/A), height-for-age (H/A), weight-for-age (W/A), upper-arm fat area (UFA), upper-arm muscle area (UMA), body fat (%BF)], and inflammation [interleukin (IL)-12, tumor necrosis factor-alpha (TNF-α), IL-10, IL-6, IL-1β, IL-8, myeloperoxidase (MPO), nitric oxide metabolites (NOx)] were evaluated before and after 90-day of supplementation with a synbiotic.<bold>Results: </bold>No significance difference was found between the baseline and end evaluations of FEV1 and nutricional status markers. A significant interaction (time vs. group) was found for IL-12 (p = 0.010) and myeloperoxidase (p = 0.036) between PCFG and SCFG, however, the difference was not maintained after assessing the groups individually. NOx diminished significantly after supplementation in the SCFG (p = 0.030). In the SCFG with positive bacteriology, reductions were found in IL-6 (p = 0.033) and IL-8 (p = 0.009) after supplementation.<bold>Conclusions: </bold>Synbiotic supplementation shown promise at diminishing the pro-inflammatory markers IL-6, IL-8 in the SCFG with positive bacteriology and NOx in the SCFG in children/adolescents with CF.
- Subjects
CYSTIC fibrosis treatment; COMPARATIVE studies; CYSTIC fibrosis; DIETARY supplements; INTERLEUKINS; LACTOBACILLUS acidophilus; RESEARCH methodology; MEDICAL cooperation; NUTRITIONAL assessment; RESEARCH; STATISTICAL sampling; TUMOR necrosis factors; EVALUATION research; BODY mass index; RANDOMIZED controlled trials; BLIND experiment; NUTRITIONAL status
- Publication
European Journal of Clinical Nutrition, 2018, Vol 72, Issue 5, p736
- ISSN
0954-3007
- Publication type
journal article
- DOI
10.1038/s41430-017-0043-4