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- Title
OMEGA-3 FATTY ACIDS AND HYPERTENSION IN HUMANS.
- Authors
Mori, Trevor A.
- Abstract
1. Population studies and clinical trials provide compelling evidence that omega-3 (ω3) fatty acids have cardioprotective effects. The strongest evidence is from DART and GISSI-P, two secondary prevention trials in patients with previous myocardial infarctions. Data from these trials support a reduction in ventricular fibrillation as a primary mechanism for the decreased incidence of myocardial infarction. 2. Evidence suggests that ω3 fatty acids may also provide protection against stroke, particularly ischaemic stroke. 3. The cardioprotective effects of ω3 fatty acids relate to improvements in blood pressure, cardiac function, arterial compliance and vascular function, as well as improved lipid metabolism, antiplatelet and anti-inflammatory effects. 4. Clinical trials in humans have shown that eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have different haemodynamic properties. Docosahexaenoic acid may be more favourable in lowering blood pressure and heart rate, as well as improving vascular function. However, the effects of EPA and DHA may also differ depending on the target population.
- Subjects
FATTY acids; CLINICAL trials; MYOCARDIAL infarction; VENTRICULAR fibrillation; BLOOD pressure; CORONARY disease
- Publication
Clinical & Experimental Pharmacology & Physiology, 2006, Vol 33, Issue 9, p842
- ISSN
0305-1870
- Publication type
Article
- DOI
10.1111/j.1440-1681.2006.04451.x