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- Title
Reno-protective effect of garlic extract against immobilization stress induced changes in rats.
- Authors
Zaidi, Syed Kashif; Ansari, Shakeel Ahmed; Ashraf, Ghulam Md.; Jafri, Mohammad Alam; Tabrez, Shams; Banu, Naheed
- Abstract
Objective To examine immobilization stress-induced antioxidant defense alterations in rat kidney and the antioxidant effects of aqueous garlic extract in pre and post stress extract treatments. Methods Albino rats were treated with aqueous extract of garlic both before and 6 h of immobilization stress. Pro-oxidant eminence of rat kidney was assessed by determining the levels of glutathione, thiobarbituric acid reactive substances, aspartate aminotransferase, alanine aminotransferase, glucose, uric acid, alkaline phosphatase and antioxidant enzymes activities. Results In response to 6 h of immobilization stress, a significant rise in the level of kidney enzymes was recorded. However, antioxidant enzyme activities showed a sharp decline. Conclusions The extract treatment before and after the stress reverted the activities of above mentioned enzymes towards their control values. Hence, garlic extract can be given as nutritional supplement for scavenging the free radicals generated in rat kidney.
- Subjects
THERAPEUTIC use of garlic; ANTIOXIDANTS; AQUEOUS solutions; PHYSIOLOGICAL stress; GLUTATHIONE; AMINOTRANSFERASES; LABORATORY rats
- Publication
Asian Pacific Journal of Tropical Biomedicine, 2015, Vol 5, Issue 5, p364
- ISSN
2221-1691
- Publication type
Article
- DOI
10.1016/S2221-1691(15)30370-1