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- Title
APE1/Ref-1 as a Serological Biomarker for the Detection of Bladder Cancer.
- Authors
Ju Hyun Shin; Sunga Choi; Yu Ran Lee; Myoung Soo Park; Yong Gil Na; Kaikobad Irani; Sang Do Lee; Jin Bong Park; Jin Man Kim; Jae Sung Lim; Byeong Hwa Jeon
- Abstract
Purpose Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a multifunctional protein that shows elevated expression in a number of cancers. We attempted to determine whether serum APE1/Ref-1 is elevated in patients with bladder cancer. Materials and Methods Serum APE1/Ref-1 levels were determined using enzyme-linked immunosorbent assay in serum from patients with bladder cancer who had not received chemotherapy or radiotherapy (n=51) and non-tumor controls (n=55). The area under the receiver operating characteristic area under the curve was applied to determine the correlation between clinical factors and the serum levels of APE1/Ref-1. Results Serum levels of APE1/Ref-1 in bladder cancer patients were significantly elevated compared to those of the control group (3.548±0.333 ng/100 μL [n=51] for bladder cancer vs. 1.547±0.319 ng/100 μL [n=55] for the control group), with a sensitivity and specificity of 93% and 59%, respectively. Serum APE1/Ref-1 levels are associated with tumor stage, grade, muscle invasion, and recurrence. Conclusion Serum APE1/Ref-1 might be useful as a potential serologic biomarker for bladder cancer.
- Subjects
APURINIC acid; ENDONUCLEASES; BLADDER cancer; BIOMARKERS; ENZYME-linked immunosorbent assay
- Publication
Cancer Research & Treatment, 2015, Vol 47, Issue 4, p823
- ISSN
1598-2998
- Publication type
Article
- DOI
10.4143/crt.2014.074