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- Title
Experimental Models of Neuroimmunological Disorders: A Review.
- Authors
da Silva, Ana Paula Bornes; Silva, Rodrigo Braccini Madeira; Goi, Leise Daniele Sckenal; Molina, Rachel Dias; Machado, Denise Cantarelli; Sato, Douglas Kazutoshi
- Abstract
Immune-mediated inflammatory diseases of the central nervous system (CNS) are a group of neurological disorders in which inflammation and/or demyelination are induced by cellular and humoral immune responses specific to CNS antigens. They include diseases such as multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD), acute disseminated encephalomyelitis (ADEM) and anti-NMDA receptor encephalitis (NMDAR encephalitis). Over the years, many in vivo and in vitro models were used to study clinical, pathological, physiological and immunological features of these neuroimmunological disorders. Nevertheless, there are important aspects of human diseases that are not fully reproduced in the experimental models due to their technical limitations. In this review, we describe the preclinical models of neuroimmune disorders, and how they contributed to the understanding of these disorders and explore potential treatments. We also describe the purpose and limitation of each one, as well as the recent advances in this field.
- Subjects
ANTI-NMDA receptor encephalitis; CENTRAL nervous system diseases; POSTVACCINAL encephalitis; NEUROLOGICAL disorders; HUMORAL immunity; NEUROMYELITIS optica
- Publication
Frontiers in Neurology, 2020, Vol 11, p1
- ISSN
1664-2295
- Publication type
Article
- DOI
10.3389/fneur.2020.00389