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- Title
Deneysel sigara modelinde resveratrolün total oksidan/antioksidan kapasite üzerine etkilerinin Araştırılması.
- Authors
Şahin, Özge Kolkesen; Aksoy, Müge Çına; Uz, Efkan; Dağdeviren, Birsen Harun
- Abstract
The harmful effects of smoking on body are known to be caused by oxidative stress in tissues. With the many harmful substances in smoke it serve as a good model of free radical damage could be monitored. The agents preventing free radical induced oxidation, capable of trapping and stabilizing free radicals are called 'antioxidants". Resveratrol is a powerful antioxidant that has anti-inflammatory, analgesic and osteogenic effects. In this study we evaluated the effects of smoking and resveratrol on oxidative stress. Material-Method For 4 weeks rats were inhalated cigarette smoke (6 cigarette/ day) and after that time 20 mg/kg/day resveratrol was given via oral gavage during 28 days together with cigarette smoke. At the end of 8 weeks total exposure to cigarette smoke, rats were sacrified and bloods and tongue samples were collected. Biochemically serum and tissue total antioxidant / oxidant capacity (TAC / TOC) were evaluated. Results There were no statistical difference between groups in terms of TAC and TOC serum. TAC tongue is higher in cigarette+resveratrol and cigarette groups. Discussion In the experiment performed with 6 cigarettes per day for 8 weeks, toxic effect of cigarette induced antioxidant system in the organism to protect the body and that is more effective than antioxidant effect of resveratrol.
- Publication
SDU Journal of Health Science Institute / SDÜ Saglik Bilimleri Enstitüsü Dergisi, 2015, Vol 6, Issue 1, p10
- ISSN
2146-247X
- Publication type
Article